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Enhanced penetration strategies for transdermal delivery

Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3,   Pages 378-388 doi: 10.1007/s11705-019-1913-1

Abstract: Transdermal delivery offers several advantages in drug distribution, including convenience, painlessdelivery.Therefore, extensive application of transdermal delivery in medical treatment has been limited.delivery.This review summarizes various formulation strategies proposed for transdermal delivery and their application

Keywords： transdermal delivery     stratum corneum     enhanced penetration     therapeutics    

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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects Review

Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu

Engineering 2023, Volume 30, Issue 11,   Pages 170-189 doi: 10.1016/j.eng.2023.05.009

Abstract: biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermaldelivery efficiency for robust therapeutic outcomes.

Keywords： Microneedles     Transdermal drug delivery system     Skin disorders     Treatments     Challenges     Prospects    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy- -PMA). Various grades of Psy- -PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

Keywords： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 521-528 doi: 10.1007/s11705-017-1612-8

Abstract: The application of gene delivery materials has been mainly focused on mammalian cells while rarely extendedThis study therefore widens the utilities of helical polypeptide as a unique category of gene deliverymaterials, and may find their promising applications toward plant gene delivery.

Keywords： α-helical polypeptide     plant gene delivery     protoplast     intact leaves     transfection    

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:
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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 276-279 doi: 10.1007/s11705-014-1426-x

Abstract: The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze ourabilities, and design the future technologies that will propel us to achieve the next level of drug deliveryEffective drug delivery systems can be developed by overcoming formulation barriers and/or biologicalso that they can be overcome by engineering manipulation of the drug delivery systems.The new generation of drug delivery scientists needs to be aware of the successes and limitations of

Keywords： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

Keywords： bioorthogonal reaction     cancer therapy     metabolic glycoengineering     bioorthogonal catalytic patch    

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Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 473-480 doi: 10.1007/s11684-016-0479-

Abstract: We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital locatedmodels to compare the mean medical expenditures between insured and uninsured women undergoing caesarean deliveryThese findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures

Keywords： maternity insurance scheme     financial incentive     caesarean delivery     medical expenditure     China    

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Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm

Trina SOM, Niladri CHAKRABORTY

Frontiers in Energy 2012, Volume 6, Issue 1,   Pages 12-20 doi: 10.1007/s11708-012-0172-3

Abstract: evaluation of a network of distributed energy resources (DERs) comprising a microgrid structure of power deliveryfor optimal power operation pertaining to minimum cost have been made for two cases in Indian power delivery

Keywords： distributed energy resources (DERs)     microgrid     tuned genetic algorithm (TGA)    

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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 221-237 doi: 10.1007/s11705-020-1927-8

Abstract: focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug deliveryThe potential risks of using ZIF-8 for drug delivery are also summarized.

Keywords： zeolitic imidazolate framework-8 (ZIF-8)     synthesis methods     applications     drug delivery    

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: Thus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailabilityalmost unchanged bioactivity in the gastrointestinal tract before release, as well as improved oral delivery

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Barriers to advancing nanotechnology to better improve and translate nanomedicines

Yuwei WANG,David W. Grainger

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 265-275 doi: 10.1007/s11705-014-1442-x

Abstract: Engineered nanomaterials and nanotechnologies promise many benefits to enhance both and performance. This is now manifest in the increasing number of reported biomedical products under development and testing that contain nanotechnologies as their distinguishing performance—enhancing components. In many cases, nano-sized materials are selected to provide a specific functional aspect that contributes to improved medical performance, either or . Nanoparticles are most commonly exploited in diverse roles in topical lotions and creams, solubilization aids, for and diagnostic and targeting agents in nanomedicines and theranostics. Despite fundamental scientific excitement and many claims to nanotechnology-based improvements in new biomedical applications, several fundamental and long-standing challenges remain to be addressed using nanomedicines to make clinically important progress. This review addresses several issues that must be fairly and objectively reported and then overcome to provide truly credible performance for nanomedicines.

Keywords： nanotechnology     nanomedicine     drug delivery     therapeutic     target delivery    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architectureHowever, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by theThis short review presents a brief introduction to RNAi therapeutics, the obstacles to their deliveryfor siRNA delivery.as well as the related structural alterations to enhance delivery efficiency.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 496-507 doi: 10.1007/s11705-013-1362-1

Abstract: In principal and practice, only the application of an appropriately designed drug delivery system (DDS) is able to overcome such limitations, and yet the cost of developing a novel drug delivery system isdeveloping new drugs in the past to a combined mode of developing both new drugs and innovative drug deliveryhow to solve these problems simultaneously and collectively via the development of innovative drug deliveryecho the desire to industrialized countries such as China to set up its strategic plan on developing delivery

Keywords： delivery systems     bio-macromolecular drugs     cell penetrating peptides    

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Title Author Date Type Operation

Enhanced penetration strategies for transdermal delivery

Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu

Journal Article

Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects

Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Journal Article

Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Journal Article

Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Journal Article

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Journal Article

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Journal Article

Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Journal Article

Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm

Trina SOM, Niladri CHAKRABORTY

Journal Article

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Journal Article

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Barriers to advancing nanotechnology to better improve and translate nanomedicines

Yuwei WANG,David W. Grainger

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Journal Article